The world-famous Mahendra Highway runs for 1024 km across Nepal, through primeval forests, across mountain deserts and tropical regions, and past the icy peaks of the Himalayas. Natural wonders alternate with cultural sites, places of pilgrimage with vibrant bazaars, Buddhist sanctuaries with sacred Hindu temples. This documentary takes us on a journey along this ancient trade route from east to west, through a land of ancient cultures and many peoples, surrounded by adventure and challenges.